Publications

Arc-mediated plasticity in the paraventricular thalamic nucleus promotes habituation to stress

Corbett BF, Luz S, Arner J, Vigderman A, Urban K, Bhatnagar S.

Biological Psychiatry. 2022 Feb 21. doi: 10.1016/j.biopsych.2022.02.012 (in press, journal pre-proof)

FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety

Corbett BF, Luz S, Sotuyo N, Pearson-Leary J, Moorthy GS, Zuppa AF, Bhatnagar S.

Physiol Behav. 2021 Oct 15;240:113556. doi: 10.1016/j.physbeh.2021.113556. Epub 2021 Aug 12. PMID: 34390688.

A daily diary study of nightmare reports among combat-exposed Veterans

Miller K, Goldstein E, Barilla H, Carroll R, Ross R, Kling M, Bhatnagar S, Gerhman P.

Sleep, Volume 44, Issue Supplement_2, May 2021, Page A286. doi: 10.1093/sleep/zsab072.729.

Sex differences in stress-induced sleep deficits

Gargiulo AT, Jasodanand V, Luz S, O'Mara L, Kubin L, Ross RJ, Bhatnagar S, Grafe LA.

Stress. 2021 Sep;24(5):541-550. doi: 10.1080/10253890.2021.1879788. Epub 2021 Feb 12. PMID: 33525935.

The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats

Pearson-Leary J, Zhao C, Bittinger K, Eacret D, Luz S, Vigderman AS, Dayanim G, Bhatnagar S.

Mol Psychiatry. 2020 May;25(5):1068-1079. doi: 10.1038/s41380-019-0380-x. Epub 2019 Mar 4. PMID: 30833676.

Passive Coping Strategies During Repeated Social Defeat Are Associated With Long-Lasting Changes in Sleep in Rats

Grafe LA, O'Mara L, Branch A, Dobkin J, Luz S, Vigderman A, Shingala A, Kubin L, Ross R, Bhatnagar S.

Front Syst Neurosci. 2020 Feb 19;14:6. doi: 10.3389/fnsys.2020.00006. Erratum in: Front Syst Neurosci. 2021 Oct 05;15:782603. PMID: 32140101; PMCID: PMC7043017.

The effects of early life adversity on growth, maturation, and steroid hormones in male and female rats

Eck SR, Ardekani CS, Salvatore M, Luz S, Kim ED, Rogers CM, Hall A, Lee DE, Famularo ST, Bhatnagar S, Bangasser DA.

Eur J Neurosci. 2020 Jul;52(1):2664-2680. doi: 10.1111/ejn.14609. Epub 2019 Nov 24. PMID: 31660665; PMCID: PMC8027906.

Interleukin-1α in the ventral hippocampus increases stress vulnerability and inflammation-related processes

Pearson-Leary J, Eacret D, Bhatnagar S.

Stress. 2020 May;23(3):308-317. doi: 10.1080/10253890.2019.1673360. Epub 2019 Oct 12. PMID: 31559913.

Sex- and Stress-Dependent Effects on Dendritic Morphology and Spine Densities in Putative Orexin Neurons

Grafe LA, Geng E, Corbett B, Urban K, Bhatnagar S.

Neuroscience. 2019 Oct 15;418:266-278. doi: 10.1016/j.neuroscience.2019.08.026. Epub 2019 Aug 20. PMID: 31442567; PMCID: PMC6922092.

Sphingosine-1-phosphate receptor 3 in the medial prefrontal cortex promotes stress resilience by reducing inflammatory processes

Corbett BF, Luz S, Arner J, Pearson-Leary J, Sengupta A, Taylor D, Gehrman P, Ross R, Bhatnagar S.

Nat Commun. 2019 Jul 17;10(1):3146. doi: 10.1038/s41467-019-10904-8. PMID: 31316053; PMCID: PMC6637233.

Endocannabinoids, stress signaling, and the locus coeruleus-norepinephrine system

Wyrofsky RR, Reyes BAS, Zhang XY, Bhatnagar S, Kirby LG, Van Bockstaele EJ.

Neurobiol Stress. 2019 May 25;11:100176. doi: 10.1016/j.ynstr.2019.100176. PMID: 31236436; PMCID: PMC6582240.

Neurochemically distinct circuitry regulates locus coeruleus activity during female social stress depending on coping style

Reyes BAS, Zhang XY, Dufourt EC, Bhatnagar S, Valentino RJ, Van Bockstaele EJ.

Brain Struct Funct. 2019 May;224(4):1429-1446. doi: 10.1007/s00429-019-01837-5. Epub 2019 Feb 14. PMID: 30767070; PMCID: PMC6510627.

Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear

Dustrude ET, Caliman IF, Bernabe CS, Fitz SD, Grafe LA, Bhatnagar S, Bonaventure P, Johnson PL, Molosh AI, Shekhar A.

Front Neurosci. 2018 Dec 18;12:934. doi: 10.3389/fnins.2018.00934. PMID: 30618563; PMCID: PMC6305451.

Orexins and stress.

Grafe LA, Bhatnagar S.

Front Neuroendocrinol. 2018 Oct;51:132-145. doi: 10.1016/j.yfrne.2018.06.003. Epub 2018 Jun 19. Review.

The contribution of orexins to sex differences in the stress response.

Grafe LA, Bhatnagar S.

Brain Res. 2018 Aug 3. pii: S0006-8993(18)30411-6. doi: 10.1016/j.brainres.2018.07.026. [Epub ahead of print] Review.

Sex- and Age-dependent Effects of Orexin 1 Receptor Blockade on Open-Field Behavior and Neuronal Activity.

Blume SR, Nam H, Luz S, Bangasser DA, Bhatnagar S.

Neuroscience. 2018 Jun 15;381:11-21. doi: 10.1016/j.neuroscience.2018.04.005. Epub 2018 Apr 18.

Orexin signaling during social defeat stress influences subsequent social interaction behaviour and recognition memory.

Eacret D, Grafe LA, Dobkin J, Gotter AL, Renger JJ, Winrow CJ, Bhatnagar S.

Behav Brain Res. 2018 Jun 11. pii: S0166-4328(18)30415-7. doi: 10.1016/j.bbr.2018.05.032. [Epub ahead of print]

Reduced Orexin System Function Contributes to Resilience to Repeated Social Stress.

Grafe LA, Eacret D, Dobkin J, Bhatnagar S.

eNeuro. 2018 Apr 16;5(2). pii: ENEURO.0273-17.2018. doi: 10.1523/ENEURO.0273-17.2018. eCollection 2018 Mar-Apr.

A Retrospective Study of Predictors of Return to Duty versus Medical Retirement in an Active Duty Military Population with Blast-Related Mild Traumatic Brain Injury.

Cook PA, Johnson TM, Martin SG, Gehrman PR, Bhatnagar S, Gee JC.

J Neurotrauma. 2018 Apr 15;35(8):991-1002. doi: 10.1089/neu.2017.5141. Epub 2018 Mar 1.

Sex differences in circuits activated by corticotropin releasing factor in rats.

Salvatore M, Wiersielis KR, Luz S, Waxler DE, Bhatnagar S, Bangasser DA.

Horm Behav. 2018 Jan;97:145-153. doi: 10.1016/j.yhbeh.2017.10.004. Epub 2017 Dec 14.

Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress.

Grafe LA, Eacret D, Luz S, Gotter AL, Renger JJ, Winrow CJ, Bhatnagar S.

Neuroscience. 2017 Apr 21;348:313-323. doi: 10.1016/j.neuroscience.2017.02.038. Epub 2017 Feb 28.

Orexins Mediate Sex Differences in the Stress Response and in Cognitive Flexibility.

Grafe LA, Cornfeld A, Luz S, Valentino R, Bhatnagar S.

Biol Psychiatry. 2017 Apr 15;81(8):683-692. doi: 10.1016/j.biopsych.2016.10.013. Epub 2016 Oct 18.

Resilience to the effects of social stress: evidence from clinical and preclinical studies on the role of coping strategies.

Wood SK, Bhatnagar S.

Neurobiol Stress. 2015 Jan 1;1:164-173.

Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood.

Hsu DT, Kirouac GJ, Zubieta JK, Bhatnagar S.

Front Behav Neurosci. 2014 Mar 11;8:73. doi: 10.3389/fnbeh.2014.00073. eCollection 2014. Review.

Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response.

Li Y, Panossian LA, Zhang J, Zhu Y, Zhan G, Chou YT, Fenik P, Bhatnagar S, Piel DA, Beck SG, Veasey S.

Sleep. 2014 Jan 1;37(1):51-64. doi: 10.5665/sleep.3306.

Enkephalin and dynorphin mRNA expression are associated with resilience or vulnerability to chronic social defeat stress.

Bérubé P, Laforest S, Bhatnagar S, Drolet G.

Physiol Behav. 2013 Oct 2;122:237-45. doi: 10.1016/j.physbeh.2013.04.009. Epub 2013 May 9.

Social stress engages opioid regulation of locus coeruleus norepinephrine neurons and induces a state of cellular and physical opiate dependence.

Chaijale NN, Curtis AL, Wood SK, Zhang XY, Bhatnagar S, Reyes BA, Van Bockstaele EJ, Valentino RJ.

Neuropsychopharmacology. 2013 Sep;38(10):1833-43. doi: 10.1038/npp.2013.117. Epub 2013 May 10.

Manganese-enhanced magnetic resonance imaging (MEMRI) reveals brain circuitry involved in responding to an acute novel stress in rats with a history of repeated social stress.

Bangasser DA, Lee CS, Cook PA, Gee JC, Bhatnagar S, Valentino RJ.

Physiol Behav. 2013 Oct 2;122:228-36. doi: 10.1016/j.physbeh.2013.04.008. Epub 2013 May 2.

Depressive and cardiovascular disease comorbidity in a rat model of social stress: a putative role for corticotropin-releasing factor.

Wood SK, McFadden KV, Grigoriadis D, Bhatnagar S, Valentino RJ.

Psychopharmacology (Berl). 2012 Jul;222(2):325-36. doi: 10.1007/s00213-012-2648-6. Epub 2012 Feb 10.

Lack of elevations in glucocorticoids correlates with dysphoria-like behavior after repeated social defeat.

Bowens N, Heydendael W, Bhatnagar S, Jacobson L.

Physiol Behav. 2012 Feb 28;105(4):958-65. doi: 10.1016/j.physbeh.2011.10.032. Epub 2011 Nov 12.

Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.

Heydendael W, Sharma K, Iyer V, Luz S, Piel D, Beck S, Bhatnagar S.

Endocrinology. 2011 Dec;152(12):4738-52. doi: 10.1210/en.2011-1652. Epub 2011 Oct 4.

Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats.

Hong S, Flashner B, Chiu M, ver Hoeve E, Luz S, Bhatnagar S.

Physiol Behav. 2012 Jan 18;105(2):269-75. doi: 10.1016/j.physbeh.2011.08.036. Epub 2011 Sep 2.

Early adolescence as a critical window during which social stress distinctly alters behavior and brain norepinephrine activity.

Bingham B, McFadden K, Zhang X, Bhatnagar S, Beck S, Valentino R.

Neuropsychopharmacology. 2011 Mar;36(4):896-909. doi: 10.1038/npp.2010.229. Epub 2010 Dec 22.

Enduring and sex-specific effects of adolescent social isolation in rats on adult stress reactivity.

Weintraub A, Singaravelu J, Bhatnagar S.

Brain Res. 2010 Jul 9;1343:83-92. doi: 10.1016/j.brainres.2010.04.068. Epub 2010 May 28.

Individual differences in reactivity to social stress predict susceptibility and resilience to a depressive phenotype: role of corticotropin-releasing factor.

Wood SK, Walker HE, Valentino RJ, Bhatnagar S.

Endocrinology. 2010 Apr;151(4):1795-805. doi: 10.1210/en.2009-1026. Epub 2010 Feb 16.